The value of making intensive, tissue-particular maps of protein lysine acetylation sites is additional underscored by the significant position of posttranslational modifications in the evolution and phenotypic composition of vertebrates, as indicated by the numerous selective pressure gene regulatory elements near posttranslational-modifying enzymes have come beneath in placental animals ( Lowe et al., 2011 ). Right here, solicitor uk we combined an environment friendly technique for protein extraction from tissue samples with lysine-acetylated peptide immunoprecipitation and excessive-accuracy tandem mass spectrometric (MS/MS) measurements, which allowed us to generate an atlas of lysine acetylation websites in sixteen totally different rat tissues.

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